Sr. No

Project Title

Investigators

Date of Initiation

Date of completion

Total  Funds allocated

Funding Agency

1.

WOMAN Trial:

Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum hemorrhage (WOMAN): an international, randomized, double-blind, placebo-controlled trial

Prof. Ian Roberts,

Prof. Haleema Shakur, Prof. Rizwana Chaudhri, Dr. Aasia Kayani, Dr. Kiran Javaid

2011

2017

 

LSHTM Collaboration.

2.

CRASH 3 Trial:

Tranexamic Acid for the Treatment of Significant traumatic brain injury: An International Randomized, Double-Blind, Placebo-Controlled trial

Prof. Ian Roberts,

Prof. Haleema Shakur, Prof. Rizwana Chaudhri, Dr. Aasia Kayani, Dr. Kiran Javaid

2015

2019

=£384780

 

UK Medical Research Council LSHTM Collaboration.

3

HALT AT TRIAL:

Tranexamic Acid for the Treatment of Gastrointestinal Bleeding: An International Randomized, Double-Blind, Placebo-Controlled Trial

Prof. Ian Roberts, Prof. Haleema Shakur, Prof Matiullah Khan, Prof Rizwana Chaudhri, , Dr. Aasia Kayani, Dr. Kiran Javaid

2016

2019

£87500

National Institute of Health Research UK

4.

Title: Factors behind the growing rate of unnecessary caesarian sections in three tertiary care hospitals of Rawalpindi, Pakistan

Prof Rizwana Chaudhri,

13 June 2019

31st July 2019

8000USD

WHO

5.

STI Transmission In Antenatal Patients

Title: Determination of the acceptability and feasibility of genital Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis screening in routine antenatal care in Rawalpindi, Pakistan

: Prof Rizwana Chaudhri

August 2019

 

43037 USD

Cepheid and UCLA David Geffen School of Medicine and Fielding School of Public Health, California.

 

6.

Gloss, The Global Maternal Sepsis Study

Prof Rizwana Chaudhri

September 2017

 May 2018.

 

WHO

7.

Feeding Practice and Gut Comfort in Healthy Full-term Infants: a Multi-country, Cross-sectional Observational Study

 

Prof Rai Asghar , Dr. Muhammad Hussain

2019

2020

400000 PKR

Nestec Ltd Switzerland, Study Management by International Contract Research Organization Covance, USA and Local representative Dimension Research, Pakistan

8.

Safe Childbirth Check List

Professor Saima Ameen, Prof Rizwana Chaudhri

March 2019  .

 

October 2019

Nill

Rawalpindi Medical University, Fatima Jinnah Medical University, Rawalpindi and Health Services Academy, Islamabad

9.

To evaluate Parameters used in different scoring systems for severity of acute pancreatitis and formulate a new scoring system to assess the severity of acute pancreatitis

Dr. Muhammad Umar

Dr. Muhammad Hanif, Dr. Tanvir Hussain

 

April 2019

August 2020

Nill

Nill

10.

Changing Antimicrobial Resistance Pattern of Bacterial isolates from intensive care units of tertiary care hospitals

Prof. Naeem Akhtar, Dr Shireen Rafiq, Dr Fareeha Sardar

2019

2020

Nill

Nill

11.

 Lab Diagnostic of Dengue in Current 2019 outbreak/

Drawing a model to predict the Dengue outbreak in Pakistan

Prof. Muhammad Umar, Dr. Shazia Zeb, Dr. Haroon Rashid

 

2019

2019

Nill

Nill

Projects completed

On going Projects

Project 1

Title: Mathematical modeling to study Transmission Dynamics of Infectious Diseases in Pakistan:

Collaboration: Rawalpindi Medical University, Pakistan and Georgia State University, USA

Principal investigator: Dr. Shireen Rafiq Department of Pathology, RMU

Co-Investigator: Dr. Naeem Akhtar, Prof. of Pathology & Dean Basic Sciences, RMU

Dr. Muhammad Umar, Vice-Chancellor, Rawalpindi Medical University, Rawalpindi

Dr. Gerardo Chowell, Prof. School of Public Health, Georgia State University

Dr. Amna Tariq (Ph. D Scholar) Infectious diseases, Georgia State University

Approved by: The Institutional Research Forum of GSU, USA, and RMU, Pakistan (27th Oct 2018)

MOU: Signed between the two universities (3rd May 2019)

Name of the Funding agency: Nill

Total Funds Allocated: Non -Funded Technical Assistance.

Summary

Infectious diseases are causing the deaths of millions of people in Pakistan. This study will help to intervene and strategize policies and response measures in the required time frame to be able to control the epidemics. Mathematical and phenomenological modeling of infectious diseases in spatiotemporal (time and space) dimensions will allow us to model, forecast, predict, and map disease and disease clusters. It will provide tools and skills for a timely response to disease outbreaks

This project will benefit us in understanding the dynamics of infectious diseases in our area. We will better understand the variables involved in the disease transmission, which if controlled can lead to a mitigation of these diseases. It will identify and help prevent future outbreaks in Pakistan

It will help in research development, validation, and translation of infectious disease modeling in the spatiotemporal dimensions for infectious diseases. To make recommendations to the health care professionals in Pakistan for the implementation of population-level interventions to mitigate the future epidemics of these diseases. To predict the upcoming epidemics of diseases in Pakistan

 

Project 2:

Title: IMPACT smoking cessation support for people with severe mental illness in South Asia (IMPACT 4S): a protocol for a randomized controlled pilot and feasibility trial for a combined behavioral and pharmacological support intervention.

Short title: IMPACT 4S pilot and feasibility trial

 

Collaboration: the University of York and all other collaborating institutions and organizations of India, Pakistan, and the UK

Principal Investigators

  1. Prof Asad Tamizuddin Nizami, Chairperson, Institute of Psychiatry, WHO Collaborating Centre for Mental Health and Research. Rawalpindi Medical University, Rawalpindi Pakistan
  2. Dr. Noreen Mdege. Department of Health Sciences, Faculty of Science, University of York, UK
  3. Professor Simon Gilbody. Department of Health Sciences, University of York, UK
  4. Prof Pratima Murthy. Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), India

Co-investigators from Pakistan: Dr. Faiza Aslam (country lead), Ms. Maryam Noor.

International Co-investigators:

University of York, UK: Dr. Gerardo Zavala, Prof. Kamran Siddiqi, Dr. Najma Siddiqi, and Prof.Catherine Hewitt

National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India:

Dr. Krishna Prasad, Prof. Santosh Kumar Chaturvedi, Dr. Arun Kandasamy

University of Leeds, UK: Dr. Ian Kellar, Dr.Tolib Mirzoev

Valid Research UK: Dr. Cath Jackson

London School of Economics, UK: Assoc. Prof. David McDaid

Approved by: Ref #: R-48/RMU, dated 24th August 2019

MOU:

The Contract of IMPACT program had been signed between IOP RMU and the University of York and all other collaborating institutions and organizations of India, Pakistan, and the UK in October 2019 that encompasses all the activities of IMPACT and no individual MOU’S for the studies is available.

Total Funds: 5521175 PKR

 

Summary

To adapt evidence-based, combined behavioral and pharmacological support intervention for smoking cessation among people with severe mental illness; and test the feasibility of delivering and evaluating it in India and Pakistan. Primary outcomes (feasibility and acceptability)Recruitment rates: Quantitative assessment of the acceptability of the research will be assessed by numbers screened, number eligible, and those agreeing to participate.For Reasons for ineligibility/non-participation/non-consent of participants, the length of time required to achieve the required sample size. Retention in the study will be assessed as a proportion of those enrolled in the study who are successfully followed-up at six months. Retention in treatment will be evaluated by several study intervention sessions attended as one measure of the feasibility and acceptability of the trial interventions to participants. Intervention fidelity during the delivery of the behavioral support within the IMPACT 4S intervention, as well as for brief advice (BA) will be assessed as one measure of feasibility of intervention delivery.

Smoking cessation pharmacotherapy adherence: For those in the IMPACT 4S arm, adherence to smoking cessation pharmacotherapy will be assessed as one measure of the feasibility and acceptability of the smoking cessation pharmacotherapies to participants. Data will be checked for completeness as another measure of acceptability and feasibility of data collection methods, and to identify problem areas and solutions. For secondary outcomes, Self-reported or family/career reported continuous smoking abstinence for at least six months (only five instances of smoking allowed during the total six months) which is biochemically verified by CO concentration (CO concentration <7ppm) at six months follow-up. Point abstinence, defined as a self-report or family/career report of not smoking in the previous 7 days, assessed at one, three, and six months follow-up. Cost of delivering the IMPACT 4S and the BA interventions. Number of participants will be included 172 in total (86 in India; 86 in Pakistan)

 

Project 3:

Title: Progress of Impact SMI Survey Under Top

Investigating Mental And Physical Comorbidity: A Survey In People With Severe Mental Illness In South Asia (Impact Smi Survey)

Collaboration: the University of York and all other collaborating institutions and organizations of India, Pakistan, and the UK

Principal Investigator

Prof. Asad Tamizuddin Nizami, Chairperson, Institute of Psychiatry, WHO Collaborating Centre for Mental Health and Research. Rawalpindi Medical University, Rawalpindi Pakistan

Co-Investigators: Dr. Kamran Siddique and Gerardo Zavala Gomez, Department of Health Sciences, Faculty of Science, University of York, UK.

Dr. Krishna. Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), India Deepa Barua and Asiful Haider ARK Foundation, Dhaka, Bangladesh Ms. Sonia Mansoor (country lead), Dr. Faiza Aslam IOP, BBH, RMU, Pakistan Siham Sikandar Public Health, Health Services Academy, Islamabad, Pakistan

Other members of IMPACT team at IOP: Nida Afsheen, Rubab Ayesha, Zaheen

Amin, Aneeqa Maryam, Najma Hayat

Approved by: RMU and University of York

 MOU: has been signed between RMU and University of York, the UK in October 2018

Total Cost: 2799577PKR

 

Summary

This cross-sectional study aims to determine the prevalence and determinants of physical disorders in people with SMI attending specialist mental health facilities in South Asia.

It is a multi-country survey, 1500 Patients with SMI attending IOP will be recruited throughout one year however total sample is n=4,500 from all three countries Bangladesh, India, and Pakistan). The diagnosis of SMI will be confirmed using the MINI V-6.0. We will collect information about: physical health and related health-risk behaviors (WHO STEPs); severity of common mental disorders (PHQ-9 and GAD-7); and health-related quality of life (EQ-5D-5L). We will measure blood pressure, height, weight, and waist circumference according to WHO guidelines. We will also measure glycated hemoglobin (HbA1c), lipid profile, thyroid function, liver function, creatinine, and hemoglobin. Prevalence rates of physical health conditions and health-risk behaviors will be presented and compared with the WHO STEPs survey findings in the general population. Regression analyses will explore the association between health-risk behaviors, mental and physical health conditions.

 

Project 4

Title: Behavioral activation for depression in people with the non-communicable disease in low- and middle-income countries in South Asia: Protocol for intervention design and randomized controlled feasibility trial

Short title: Behavioral Activation for Comorbid Depression in Non-communicable Disease (BEACON) study

 

Collaboration: the University of York and all other collaborating institutions and organizations of India, Pakistan, and the UK

Principal Investigator: Prof. Asad Nizami, IOP, RMU

Co-investigators:   Prof. Jerome, Department of Health Sciences, Faculty of Science, University of York, UK

  1. Dr. Najma Siddiqi, Department of Health Sciences, Faculty of Science,

University of York, UK.

  1. Dr. Siham Sikandar, Health Services Academy, Pakistan

Co-investigators from Pakistan: Ms. Rusham Rana (country lead), Dr. Faiza Aslam, IOP, Pakistan.

Funding source: 2992000 PKR

Approved by: IRF

MOU: A contract was signed between IOP RMU and all collaborators in Oct 2018,

Summary

We aim to adapt and test the feasibility of brief psychological therapy, behavioral activation, delivered by non-specialist health workers for people with depression in non-communicable diseases in LMIC in South Asia. 

 

Project 6

Title: Digital library of medical apps, a medical professional support system

Principal Investigator: Prof. Muhammad Umar

Co-investigator: Prof. Iftikhar Hanif, Prof. Riaz Shaikh, Dr. Muhammad Osama, Dr. Syed Muhammad Ali

Approved by: Applied for Approval and Patenting

MOU signed: Between RMU and PASTIC in March 2019

Name of funding Agency: Nill

Total Funds: Nill

 

Summary

This system set-ups and aligns online medical knowledge sources for healthcare professionals. All these sources will then be gathered and composed into one single source named “medhut”.

 

This system will be based on indexation, citation, and color grading with the recommended algorithm. Varying colors will represent sources of knowledge for different levels of healthcare professionals, ranging from students to medical experts. It is unique in the fact that it also categorizes the medial apps according to the specialty that will bring a new life for learners and trainers.

 

Project 7

Title: Hepatitis Free Rawalpindi City Initiative, From Cure to control: A Project under Patron ship of Vice-Chancellor Rawalpindi Medical University

Principal investigator: Prof. Muhammad Umar

Co-investigator: Dr. Affifa Kulsoom

Name of funding Agency: Nill

Total Funds: Nill

 

Summary

  1. Awareness and prevention in community and health professionals
  2. To make Rawalpindi first hepatitis free city of Pakistan
  3. Moving from hepatitis C cure to elimination
  4. The first draft has been developed
  5. The second draft in light of suggestions of Dr. Shahzad Ali khan, HAS is under process
  6. Costing would be done once the draft is finalized

 

Project 8

Title: “Dengue Fever interpersonal Preventive awareness deliverance Impact”   A qualitative study to evaluate interpersonal health awareness approach; effectiveness & feasibility. 

Principal investigator: Prof. Dr. Arshad Sabir

Co-investigator: Dr Sana Bilal, Department of Community Medicine RMU

Name of funding Agency: Nill

Total Funds:  Nill

Summary

The current (Aug-Oct 2019) Dengue Fever Interpersonal Campaign was undertaken to avail the opportunity of availability of receptive & appropriate for IP contact population. DF Prevention Awareness Performa was designed to ensure delivery of the whole message, a ready resource for the client, and to bring objectivity in work at the end of the sender. Performa was Health Education Activity-based not for research purposes.

Proposed Research is as follows

Phase-I

  1. IP Health awareness deliverance experience; (Senders, management & logistic aspects)
  2. Focus Group Discussion
  3. Guided and Supervised by Social Science Researcher. (Dr. Faiza )
  4. Learning opportunity for RMU faculty

Phase-II (next season)

  1. IP Health awareness deliverance experience ( recipient retention of knowledge & practices change etc)
  2. New Research-based data tool will be designed
  3. Recipient participatory research ( FGD)

Sr #

Project Title

Department

Principal Investigator

1.

PROTECT

RMU, NATIONAL, COLLABORATIVE

PROF. MUHAMMAD UMAR

2

Experimental use of COVID-19 convalescent plasma for the purpose of passive immunization, in current covid-19 pandemic in Pakistan in 2020

VISITORS

RMU-NATIONAL

Prof Dr. Tahir Shamsi-NIBD Karachi

Lubna miraj Assisstant professor RMU

3.

An enabled preliminary diagnosis for covid-19 from cough samples via A mobile application

VISITORS

 

DR. UMAIR sajjid Hashmi-NUST

4.

Computational modelling for COVID-19 epidemic in pakistan

VISITORS

 

Dr. Hamza-NIH

5.

COVID-19 Detection from chest X-rays using deep learning

VISITORS

 

Miss Hira-MNCHRN

6.

Effects of COVID-19 on pregnant women, and their new borns, a prospective cohort study

VISITORS

 

Miss Hira-MNCHRN

7.

Role of telemedicine in ophthalmology practice in post Covid-19 new world order

OPHTHALMOLOGY

Dr. Saira Bano Satti

8.

Evaluation of risk of infectivity of SARS-COV2 virus via tears and conjuctival secretion of COVID-19 patients

OPHTHALMOLOGY

Dr. Ambreen Gul

9.

Impact of online mental health and psychosocial support (MHPSS) services on mental health and psychosocial wellbeing of indivisuals infected by or recovering from covid-19 in pakistan

PSYCHIATRY

Dr. Usman Hamdani, Chairman HDRF Islamabad

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