This document outlines the evidence-based guidelines for managing acute pancreatitis at Rawalpindi Medical University (RMU) and its allied hospitals, issued on May 3, 2021. A key feature is the introduction of a new institutional severity assessment tool, the “RMU criteria,” developed from a 2019 pilot study on local patients to provide a more cost-effective and simpler alternative to existing scoring systems. This new criteria, based on 9 specific parameters, demonstrated a higher sensitivity of 93.1% compared to Ranson’s, BISAP, and APACHE-II scores. The guidelines provide comprehensive recommendations on the diagnosis, initial management including aggressive fluid resuscitation, severity assessment, nutritional support favoring enteral feeding, indications for ERCP, the limited role of prophylactic antibiotics, and the timing of surgical interventions for complications like infected necrosis or gallstone pancreatitis.